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A patient with unexplained fatigue should be worked up, not injected masking a B12 deficiency of unclear cause, or an unexamined thyroid problem, with a monthly shot is a real clinical risk

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That is a workforce that is paying close attention to how they are treated

In this context, Du et al., noted loss of tissue resident macrophages in colon biopsies from patients with ulcerative colitis, that was accompanied by decreased superoxide dismutase 2 expression (an important antioxidant) in the macrophages [3]

The permeability of the blood-brain barrier, a key factor in these processes, is influenced by several variables, including the stress response and inflammatory mediators (Tate et al., 2022)

Li et al., 2014)