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This condition is known as GH deficiency (GHD) but in analogy with other pituitary deficiencies leading to peripheral hormone deficiencies the term secondary IGF-I deficiency was proposed (Rosenfeld et al)

SubQ injections require you to be comfortable with needles and have access to NAD vials, but they can be done at home in minutes

The Phase 2 retatrutide trial (PMID 37366315) reported -24.2% body weight change at the 12 mg weekly dose across 48 weeks

Earlier framings of "0.34 partial agonist at GCGR" or "0.4 softened agonist at GLP-1R" mistook potency ratios (EC50_LY EC50_native) for efficacy multipliers (E_max_LY E_max_native) and are retracted

This is part of why B12 has a strong safety record, and it is also why levels sometimes need regular replenishment during active treatment

Can support glutathione, our body's most potent detoxifying molecule