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Vitamin K is a very important prophylactic for all newborns, for example, to prevent bleeding as a side effect after vaccination, which mostly is vitamin K deficiency bleeding a serious condition in the neonatal period and early infancy [322]

The increase of IGFBP-2 in the bloodstream reflects severe brain impairment [150], potentially leading to increased binding of IGF-1 by IGFBP-2, thereby reducing IGF signaling and its biological functions [123, 148]

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