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Understanding the Science: Why GLP-1 Agonists Work for MCAS To appreciate why this discovery is so significant, we need to understand the elegant mechanism at play

Eur J Pharmacol 2003;462:10913.ArticlePubMed 7

Advanced statistical methodsincluding propensity score adjustment and calibrated hazard ratioswere applied to minimize confounding and enhance reliability

Since inhibition of FXR in intestinal L cells is able to promote GLP-1 release 11 , changes in BA composition or profiles are likely to affect glucose homeostasis by controlling insulin secretion via modulating GLP-1 production

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