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Loss of claudins 2 and 15 from mice causes defects in paracellular Na + flow and nutrient transport in gut and leads to death from malnutrition

10.1016/j.molcel.2014.05.008 [DOI] [PMC free article] [PubMed] [Google Scholar] Lyssiotis CA, Son J, Cantley LC, Kimmelman AC

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Gene knockdown experiments further revealed that SiO-induced ferroptosis and ROS elevation are mediated by NOX4 upregulation and Smad3 activation, highlighting the critical role of ferroptosis and this signaling axis in SiO-induced intraocular pressure elevation

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