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Together, they create a more powerful metabolic effect than either receptor alone, which explains why tirzepatide outperforms semaglutide in clinical comparisons

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Previous analyses placed sygl-1 and lst-1 downstream of, or parallel to, GLP-1/Notch signaling and upstream of GLD differentiation regulators, but their relationship with FBF was unresolved [18, 25] (Fig 1B)

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The inclusion is expected to improve global access and affordability, particularly in low- and middle-income nations, where diabetes management remains a significant challenge

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