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Despite the promising therapeutic potential of polyphenols like curcumin and resveratrol, their clinical application is often hindered by poor bioavailability, rapid metabolism, and low chemical stability

NRF2 also cooperates with components of the transcriptional machinery (i.e., MED16) (Sekine et al, 2016), chromatin remodelers (i.e., BRG1) (Zhang et al, 2006) and chromatin-modifying enzymes (i.e., CBP) (Katoh et al, 2001) to drive target gene expression

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This effect is mediated by the gut hormone GLP-1, which is released after food ingestion and stimulates beta cells to produce more cAMP and secrete more insulin (Doyle and Egan 2007)