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They are short-lived ions that may lead to different illnesses, including diabetes, heart disease, and even cancer by damaging cellular DNA

doi: 10.3389/fmolb.2022.1016090 Received 18 August 2022 Accepted 15 September 2022 Published 29 September 2022 Volume 9 - 2022 Edited by Ye Sun, Boston Children's Hospital, Harvard Medical School, United States Reviewed by Xudong Wang, Massachusetts General Hospital, Harvard Medical School, United States Xiujuan Shi, Tongji University, China Updates Copyright 2022 Ma, Yang, Zuo and Huang

Furthermore, HPP971 has completed two phase-I studies for the treatment of several diseases, including blood, bone, eye, kidney, and lung diseases, where it was well tolerated [66]

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Santofimia-Castao P, Garcia-Sanchez L, Ruy DC, Sanchez-Correa B, Fernandez-Bermejo M, Tarazona R, Salido GM, Gonzalez A (2015b) Melatonin induces calcium mobilization and influences cell proliferation independently of MT1/MT2 receptor activation in rat pancreatic stellate cells