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Chapter 8 - Biotechnology approaches in developing novel drug-delivery systems

Current pharmaceutical design, 17 (16), 16121632

Mass spectrometry analysis of metabolitessample preparation The liver, brain, kidney, and lung tissues were homogenized with a pre-chilled BioPulverizer (59012MS, BioSpec) and then placed on dry ice

NAD+ is designed to support cellular energy and DNA repair, while glutathione is focused on detoxification and protecting cells from oxidative stress

The peptide backbone itself is small and, like other short peptides, is subject to degradation by plasma and tissue peptidases, giving it a short intrinsic half-life

In plasma and serum, the oxidized fraction may include mixed glutathione disulfides in addition to GSSG, making matrix-specific validation essential (Tomin et al., 2020)