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Miller, D

At therapeutic doses it is safe for most people, but acetaminophen metabolism uses glutathione directly, and chronic high dose use is the leading cause of acute liver failure in the United States precisely because it exhausts hepatic glutathione (PubMed PMID: 26041729)

The review follows a shift in oversight to potentially increase access to these substances

Interaction with other ROS-processing pathways Since the elucidation of the ascorbateglutathione pathway, it has become apparent that plants have multiple pathways for ROS removal