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doi: 10.1038/s41392-023-01496-3, 6

First attempts to treat diabetes By the start of the First World War several researchers in various countries had attempted to use pancreas extracts to treat diabetes mellitus, first in dogs and then in humans

It will be difficult to engineer balanced agonism into a single small-molecule because the sequence hybridisation of the dual and triple peptide agonists has no obvious chemical analogue

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