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Eligibility criteria All clinical trial and animal studies assessing the effects of glutamine on metabolic variables (e.g., glycemic status, incretin hormones, lipid profile, oxidative stress and inflammation biomarkers) in diabetes mellitus were eligible for inclusion

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Based on the temporal relationship with the recent use of semaglutide for a five-week duration, along with the exclusion of other plausible causes, a working diagnosis of semaglutide-induced small bowel pseudo-obstruction accompanied by ileitis was established

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The samples were stored at -70C in an ultralow temperature freezer