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(2) ROS activates NF-B and MAPK signaling pathways, upregulating the expression of MMPs (MMP-13, MMP-3) and inflammatory factors (IL-1, TNF- ), thereby accelerating the degradation of type II collagen (Col-II) and proteoglycans

The study protocol was conducted according to the institutional and ethical guidelines of the care and use of laboratory animals, complied with the ARRIVE guidelines, and was approved by the ethical committee of the Faculty of Pharmacy, Ain Shams University (Egypt) (ENREC-ASU-number 133)

GLP-1 has shown potential clinical application as a biomarker and treatment option for Diabetes Mellitus, which is based on the following physiological functions mediated by GLP-1

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"Of all my medications, it's the only one not subsidised," she said, adding that she hopes GLP-1 medications will eventually be subsidised for patients using them to manage chronic, life-threatening conditions

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