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Structure The GLP-1R protein has a signal peptide (amino acids 1-23) that is cleaved as the rest of the protein (amino acids 24-463) is targeted to the endoplasmic reticulum to form a seven transmembrane helix containing protein (see extracellular (E), cytoplasmic (C), and membrane proteins (M) marked in Figure 2a)

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[Google Scholar] 32.Perkovic V., Tuttle K.R., Rossing P., Mahaffey K.W., Mann J.F.E., Bakris G., Baeres F.M.M., Idorn T., Bosch-Traberg H., Lausvig N.L., et al