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It is very difficult to make recommendations or draw valid conclusions on the effectiveness of oral supplements and systemic drugs in the treatment of skin aging, as most of the evidence is based on small, single-center studies with short follow-up periods (mostly 24 months), predominantly female samples, and use of heterogeneous methodologies and evaluation criteria

"Upping antioxidants like glutathione would likely benefit premature graying by combating the oxidative damage that is happening to the pigment producing cells called melanocytes," she said

Vitamin C also helps reduce pigmentation, improve skin brightness and support collagen production

Pharmaceutical-Grade Ingredients Verify that your provider uses USP-certified MIC/B12 blends, with complete ingredient lists and concentrations published or readily available

PMID:30342710