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It has also shown good results in lowering cardiovascular risks and thus, is also used to reduce the risk of cardiovascular events like cardiovascular death, non-fatal myocardial infarction, or non-fatal stroke, in patients with and without T2DM and established cardiovascular disease
The study also showed that cardiometabolic effects after withdrawal of semaglutide reversed significantly, with cardiovascular risk markers returning towards pre-treatment levels
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The mechanism work on this is active: GLP-1R is expressed in cardiovascular tissue, and receptor activation there appears to modulate inflammation, endothelial function, and possibly plaque biology through pathways that are not obviously downstream of insulin or appetite regulation
& de Groot, D
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