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Charles Brenner, who discovered nicotinamide riboside as an NAD+ precursor, conducted a 2016 clinical trial showing oral NR supplementation safely increased human blood NAD+ levels up to 2.7-fold [14]

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Levels decline with age, and that decline is part of why NAD+ has become a fixture of the longevity supplement conversation

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Individuals with Vitamin B12 deficiency resulting from gastrectomy or bariatric surgery, which we also provide, can benefit significantly from these injections

The above leads to the overproduction of ROS and RNS, and it intensifies cytokine and chemokine secretion via a positive feedback loop (174)