Methods: Histological analysis was performed to assess the specific distribution of innate and adaptive immune cell populations in labial salivary gland (LSG) samples from 30 patients with pSS and 13 patients with non-pSS
Statistical Analyses All statistical analyses were performed using SAS versions 9.3 or 9.4 (SAS Institute, Cary, NC, USA)
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3f), whereas mechanical allodynia was dose-dependently alleviated in the groups treated with exendin 939 (5 or 10 g) or BCTC (0.5 g), a widely used TRPV1 inhibitor 40
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By the studys end, liraglutide had elevated testosterone and SHBG to higher levels than achieved in the other groups and led to higher sperm counts and motility, earning the authors conclusion that liraglutide is a useful drug for the treatment of obese males with metabolic hypogonadism, outperforming traditional hormonal approaches This pioneering trial suggests that tackling the root cause (obesity/insulin resistance) with a GLP-1 RA can reverse obesity-related hypogonadism and improve fertility potential in men
