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Sikirica M, Martin A, Wood R, et al

A linear gradient of mobile phases was employed, where solvent A comprised 0.1% (v/v) formic acid (##1209246, Sigma Aldrich, Germany) and solvent B consisted of 80% (v/v) acetonitrile (##741857, Sigma Aldrich, USA) with 0.1% (v/v) formic acid

The authors of a 2022 review described the relationship as a vicious cycle: melatonin synthesis decreases as you grow older, and the aging process worsens because of melatonin deficiency

Barrett JS et al

No, the active ingredients are different and target different bodily mechanisms

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