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According to a recent molecular dynamics simulation study, since C8 has a greater membrane expulsion tendency after being inserted into the membrane than C10, the ratio of the remaining C8 inserted into the membrane is small, and is thought to reduce the membrane disruption effect [75]

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It is also worth noting that in obese patients with T2DM, GLP-1RA-mediated weight reduction has been associated with the detection rate of breast cancer [34], with the highest incidence observed in patients who experienced more than 10% weight loss following treatment [35]

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Secondly, significant weight loss and the resultant change in the inflammatory phenotype of obese adipose tissue would reduce the release into the circulation of key pro-fibrotic pro-inflammatory cytokines/adipokines such as TNF-, IL-6, leptin [31], visfatin and resistin, and increase levels of anti-fibrotic adipokines such as adiponectin [32]

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