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In the pathological state of ischemic stroke, inflammatory signals released by dead neurons or cytokines and chemical inducers secreted by microglia under stress could drive circulating lymphocytes to recruit to the damaged brain (61, 62)

Localized redness or irritation may occur at the subcutaneous injection site

Specifically, we performed a proof-of-concept Bayesian network meta-analysis of body-weight change only, within a prespecified 1216-weeks window, using the largest connected treatment network

215 Nrf2 is a key transcription factor that regulates cellular redox homeostasis and inflammatory response