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This observation suggests that impaired GLP-1 signaling might contribute to depression susceptibility, and that enhancing this signaling through medications like Retatrutide could provide therapeutic benefit

2016 Nov;30(11):1745-1764

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3.2.3 Immune rewiring and chronic inflammation Chronic inflammation is a key pathological consequence of dysregulated ECM remodeling in hypothyroidism-associated MAFLD and serves as a major driver of hepatic fibrogenesis

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