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The downstream effects most consistently described in the literature: induction of collagen I and III, elastin, and decorin synthesis (Maquart et al., FEBS Letters , 1988), upregulation of VEGF and basic FGF transcripts, induction of antioxidant defense genes including SOD2 and metallothionein isoforms, and modulation of the MMP-2 and TIMP-1/2 balance toward non-fibrotic remodeling

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Their specificity the ability to bind to particular receptors and trigger precise downstream events is what underpins their therapeutic potential in targeted drug delivery, often identified through phage display, and is why they have become a cornerstone of modern peptide research

doi:10.1017/S0029665118001192 [22] Kulnigg-Dabsch S