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Hypertension 2008

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Additionally, PRMTs methylate proteins from multiple layers of the DNA damage response, such as BRCA1 (Breast cancer susceptibility gene 1), 53BP1 (p53 binding protein 1), and MRE11 (meiotic recombination 11), regulating their transcription, stability, activity, subcellular location, and protein or nucleic acid interactions to adapt to genotoxic stimuli [80-82]

PubMed Seglen, P.O., 1976

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42,43 In addition, the prevalence of AMS is obviously higher in subjects with patent foramen ovale (PFO), an embryologic residual right-to-left cardiac shunt that can impair pulmonary gas exchange efficiency, than without PFO