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All cells were cultured in an endothelial cell-specific medium for human umbilical vein endothelial cells, which was supplemented with 10% fetal bovine serum and 1% penicillin/streptomycin (PCM-H-040, ZQXZbio, China)

The pattern is consistent: accelerated healing timelines in animal models, minimal adverse effects, and a glaring absence of Phase I or Phase II human trials that would validate these findings in clinical populations

Fisher's exact probability test was used to assess the number of dead and surviving rats

March 5, 2025

However, it is important to understand that 24 weeks, while substantial for clinical trials, provides limited information about safety with years-long continuous use