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Oncologist 26(5):422426 Roskoski RJ (2020) Properties of FDA-approved small molecule protein kinase inhibitors: a 2020 update

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Freezethaw cycles may: Affect molecular stability Increase aggregation risk in some formulations Reduce overall consistency of the solution Storage at 28C is typically preferred unless otherwise validated

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The monthly cost of treatment may exceed the entire annual medication budget for some patients, creating substantial access challenges