Preventing microglial activation may reduce neuronal damage and degeneration under inflammatory conditions, making it a potential therapeutic strategy for CNS disorders
Gut Health and Immune Dysregulation Visceral adipose tissue inflammation is driven, in part, by altered gut microbiota and intestinal permeability (aka leaky gut)
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Trans-10-hydroxy-2-decenoic acid protects against LPS-induced neuroinflammation through FOXO1-mediated activation of autophagy
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For example, an siRNA against mitochondrial fission protein Drp1 could potentially reduce excessive mitochondrial fragmentation in immune cells (excess fission is seen in stress and leads to dysfunction)