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doi: 10.1186/s13023-022-02344-3 185 GoldstoneAPThomasELBrynesAEBellJDFrostGSaeedNet al

In 1973, Engel and Angelini reported the first case of L-carnitine deficiency and treated it with carnitine

Several studies indicated that the inhibition of AR causes the accumulation of toxic aldehydes, such as 4-HNE [35-37], the most abundant lipid peroxidation products, also one of the substrates of AR [38]