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Hyaluronic Acid: Work as a moisture-binding agent to support skin hydration by helping retain moisture, improving smoothness and suppleness

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Metabolomics sample preparation Both unlabeled and heavy-labeled metabolites detection was conducted

Using tap water or distilled water from the store introduces contaminants

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F 2 -isoprostanes Isoprostanes are specific prostaglandin-like molecules formed by the non-enzymatic ROS-mediated peroxidation of PUFAs, involving for example arachidonic acid (Milne et al