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This work was supported by the NIH (RC2DK129964 to A.Y.T., R01-DC006982 to L.L

L-glutathione, the primary skin-brightening active, shifts melanin production from eumelanin (brown-black pigmentation) toward pheomelanin (lighter pigmentation) by reducing the oxidative environment required for eumelanin synthesis and by inhibiting tyrosinase the rate-limiting enzyme in the melanogenesis pathway

ROC curves were generated from model predictions, and diagnostic utility was quantified using the area under the curve (AUC)

Based on claims data available for the CY 2026 OPPS/ASC proposed rule, we proposed to designate six brachytherapy APCs and five clinical APCs as low volume APCs under the OPPS (90 FR 33561 through 33562)