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Phase 1 (optimization): preoperative GLP-1 RA therapy for 48 weeks to reduce liver volume and visceral fat

Since the early 2000s, the discovery of multiple regulated cell death programmes has intensified interest in targeting these maladaptive traits that cancer cells employ to resist cellular demise

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The SURMOUNT-4 trial demonstrated that continued tirzepatide treatment is necessary to maintain weight loss

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Rat models with chemically induced liver damage show measurable reductions in liver enzyme markers (AST and ALT) after peptide administration