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A growing body of evidences indicates that, over the course of the evolution of the immune system, arginine has been selected as a node for the regulation of immune responses ( There are two key enzymes involved in arginine metabolism: arginase (ARG) and nitric oxide synthase (NOS)

Barcoded peptide and polymer libraries allow parallel evaluation of thousands of candidates, rapidly identifying synergistic sequences that can be modularly integrated into GLP-1R-targeted nanoscaffolds for cargo- and disease-specific optimization [544, 545]

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Because GLP-1R and GIPR are central components of incretin physiology, GLP-RTallows researchers to explore how simultaneous receptor activation influences cyclic AMP signaling, hormone secretion pathways, and metabolic regulatory networks