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Tirzepatide represents a significant advancement in obesity and diabetes treatment, as it acts as a dual agonist for both GLP-1 and glucose-dependent insulinotropic polypeptide (GIP) receptors[1]

Cystine deprivation resulted in a time-dependent reduction of mTORC1 signaling, as evidenced by the gradual decrease in the phosphorylation of p70S6K (T389) and S6 (S235/236), which are downstream effectors of mTORC1 (Fig

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Pancreatic cancer risk in patients treated with GLP-1 receptor agonists: a 9-year nationwide cohort study

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Both trials also showed dose-dependent and marked improvements in waist circumference, lipids and blood pressure (Table 1)