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Differentiation therapy targeting the -catenin/CBP interaction in pancreatic cancer

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Even if GLP-1 and GIP secretion are present in these scenarios, both hormones usually have decreased effectiveness

The glucagonostatic effect of GLP-1 was retained in islets from Glp1r knockout mice

Abstract The GLP-1 receptor, one of the most successful drug targets for the treatment of type 2 diabetes and obesity, is known to engage multiple intracellular signaling proteins

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