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This suggests incretin effects that are independent of insulin action, as insulin levels remain low to undetectable in this state

Therefore, M3-type cholinergic receptors and GRP receptors are also involved in metformin-induced changes in GLP-1 secretion

PLoS ONE 9 , e94752 (2014)

In clinical trials, patients lost an average of 2% of their body weight per month for the first six months, then 1% per month for the next six months, totaling a 16% weight loss by the end of the first year

This stops intrinsic factor from attaching to vitamin B12, and so the vitamin cannot be absorbed into your body