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Despite other combination of dual sEH-I with PPAR- or PPAR-modulators, they discovered the first dual sEH/PPAR modulators, which were able to inhibit sEH with moderate potency and partially activate PPAR

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They are composed of a series of amino acids, which can be more than 50 in number, but which fold into exact three-dimensional shapes which are necessary for their biological function

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demonstrated that hepcidin slowed the progression of atherosclerosis by reducing iron levels in macrophages