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Of these, 5,967 were treated with semaglutide while the remaining participants were on other anti-diabetic therapies, such as metformin, insulin, SGLT2 inhibitors and other GLP-1 analogs

Endogenous GLP-1 acts in GLP-1Rs located in this region and reduces the intake of highly palatable foods by suppressing mesolimbic dopamine signaling, which controls the pleasure-directed acquisition of food [24]

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In the STEP weight trials, there were no significant interactions between treatment effect and race (STEP 1 and 3: p greater than or equal to 0.07) or ethnicity, and the weight loss versus placebo was clinically meaningful across every racial subgroup

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Luo Q, Zhang B, Kuang D, Song G