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One of the primary downstream effects of increased GH and IGF-1 is enhanced lipolysis, the process of breaking down stored fat for energy

Instead of acting on appetite hormones, it blocks some fat absorption in the digestive tract

In fact, obesity is often associated with foot pain, as well as many other health concerns

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Use of DPP-4 inhibitors, GLP-1 receptor agonists, and SGLT-2 inhibitors is on the rise owing, at least in part, to their glycemic benefits, lack of weight gain, and complementary mechanisms of action when used in combination with metformin or other antihyperglycemic medication classes