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Abbreviations ALI: Acute lung injury ALT: Alanine aminotransferase AST: Aspartate aminotransferase BALF: Bronchoalveolar lavage fluid BiMP NZs: Bimetallic manganese-platinum nanozymes CK: Creatine kinase COPD: Chronic obstructive pulmonary disease CREA: Creatinine CS: Cigarette smoking CSE: Cigarette smoke extract DEGs: Differentially expressed genes DLS: Dynamic light scattering ESR: Electron spin resonance FEV 0.05s : Forced expiratory volume in 0.05 s FVC: Forced vital capacity GSH/GSSG: The ratio of reduced glutathione to oxidized glutathione HO: Hydrogen peroxide LDH: Lactate dehydrogenase LPS: Lipopolysaccharide MDA: Malondialdehyde MLI: Mean linear intercept MM-BiMP NZs: Macrophage membrane-biomimetic bimetallic Mn-Pt nanozymes Mn-Pt: Manganese-platinum NAC: N-acetylcysteine O: Singlet oxygen O: Superoxide anions OH: Hydroxyl radicals PCO: Partial pressure of carbon dioxide PO: Partial pressure of oxygen ROS: Reactive oxygen species TEM: Transmission electron microscopy T-SOD: Total superoxide dismutase XPS: X-ray photoelectron spectroscopy XRD: X-ray diffraction References de Oca MM, Perez-Padilla R, Celli B, Aaron SD, Wehrmeister FC, Amaral AFS, et al

Operation of the pathway in vivo: unresolved issues The ascorbateglutathione pathway as understood today does not easily lend itself to the use of nuclear isotopes to estimate metabolic flux between the different reactions

The inclusion of NAC (N-Acetyl Cysteine) is particularly noteworthy, as it's a precursor to glutathione and can help boost its levels in the body

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