Calling berberine a "natural Ozempic" overstates it
CagriSema: This Novo Nordisk combination is a fixed-dose co-formulation of the GLP-1 agonist semaglutide and the long-acting amylin analogue cagrilintide
However, weight loss itself can improve insulin sensitivity and metabolic health, which may indirectly support stable testosterone levels
These homemade options cost pennies per serving compared to commercial products
In 2024, a large study of over 160,000 individuals showed that GLP-1RAs are associated with a 195% higher risk of major depression, 108% increased risk for anxiety, and 106% elevated risk for suicidal behavior
5.6 Hypoglycemia with Concomitant Use with Insulin or Insulin Secretagogues JANUMET may increase the risk of hypoglycemia when combined with insulin and/or an insulin secretagogue (e.g., sulfonylurea) [see Adverse Reactions (6)]