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The dual role of COP1 as both an independent E3 ligase and a component of the CRL4 complex suggests that it may act as a molecular switch, toggling between distinct functional modes depending on cellular context

It can be found in many plant oils, e.g

Studies have shown that, among patients with psoriasis, individuals carrying the ApaI (rs7975232) CC genotype exhibit higher six-week clinical response rates to topical calcipotriol compared with those harboring other genotypes, suggesting an association between this locus and therapeutic response [281]

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Miro1dependent mitochondrial positioning drives the rescaling of presynaptic Ca2+ signals during homeostatic plasticity

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