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Similarly, a 2009 study on ACE inhibitors like lisinopril and ramipril, conducted with 22 patients who had mild-to-moderate hypertension, revealed that exenatide did not impact the steady-state pharmacokinetics of lisinopril

Taken together, FM subjects have decreased isovaleric acid concentrations compared to HC, but these changes did not correlate with FM symptoms

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However, approval is conditional: adolescents must have severe obesity (BMI 35 or 95th percentile for age) and documented cardiovascular or metabolic complications such as type 2 diabetes, hypertension, or sleep apnea