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Initially approved by the Food and Drug Administration to treat diabetes in 2017, semaglutide became the first FDA-approved drug for weight management in 2021

Griffin WS, Sheng JG, Royston MC, Gentleman SM, McKenzie JE, Graham DI, et al

Temporary Swelling: Slight swelling in the treated area can occur but typically settles within a few days

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Briefly, the pancreas was inflated through common bile duct Collagenase XI (Sigma Aldrich, C7657) injection, mechanically disrupted using scissors and gentle shaking, and incubated with collagenase for 15 min at 37C