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The most important nutrients that help lower homocysteine levels are folate, the vitamins B12, B6 and B2, zinc and trimethylglycine (TMG)

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It is harmless even in huge amounts: Ever since B12 was isolated as a substance, it has been used in extremely high doses to treat cyanide poisoning and a range of illnesses

doi: 10.4081/MONALDI.2021.1981 239 KocHCXiaoJLiuWLiYChenG

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The more efficient conjugation of the QIs to GSH may have reduced covalent modification of cellular macromolecules, like ER proteins Grp78/Bip (Xu et al., 2015), microsomal GST (Weis et al., 1992), and PDI (Liu et al., 2005)