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Bradykinesia, or slowness of movement (in particular, difficulty to initiate a movement), is often one of the earliest symptoms of PD and can affect activities such as walking, writing, and performing daily tasks

J Allergy Clin Immunol 125 (2, Suppl 2):S3S23

This level is generally considered effective yet gentle enough to minimize the risk of irritation, especially for sensitive skin types

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2021;7(13): eabf9180

(PMID: 16186419) Wang, Zhang, Huang, and colleagues published a dose-response meta-analysis in PLoS ONE in 2017, analyzing nine prospective studies with 527,589 participants