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Retatrutide is an effective triple-receptor agonist that works by slowing stomach emptying, regulating appetite, and boosting energy metabolism
The abdomen, front of the thighs, and back of the upper arms work best for this
In contrast, another GLP1R agonist , with a shorter half-life of around 13 hours (Liraglutide) achieved only 5.5% reduction in the same time span [22] , demonstrating that improving half-life can result in better outcomes
however, oral drugs need further data in order to confirm their status as a true alternative to injectables
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