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The applicant also noted that after propensity-score weighting, the study considered all differences in the reason(s) for cystoscopy to be negligible and collected data from a single institution's integrated electronic medical record

This leads to the release and subsequent cytoplasmic translocation of p53, which in turn activates a transcription-independent pro-apoptotic pathway, facilitating the selective clearance of senescent cells (Kong et al., 2025