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Whether this is due to the limited increase in GLP-1 from 3.3 pM 0.5 pM (before LFD) to 3.6 pM 0.9 pM (after LFD) should be investigated in future studies

In knock-in mice expressing DOR-eGFP, a challenge with SNC-80 but not ARM-390 induces a tolerance to analgesic response in a model of inflammatory pain with a concomitant G protein uncoupling in both brain and spinal cord homogenates (Pradhan et al., 2009)

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There is no formal contraindication, but you should consult your GP or prescribing clinician before combining them