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This interaction blocks Keap1s ubiquitin-dependent degradation of NRF2, stabilizing the protein and promoting its nuclear translocation and transcription of target genes, thereby forming a p62-Keap1-NRF2 positive feedback loop
In the intervention of ferroptosis-related diseases, current therapeutic strategies face considerable challenges
General peptide safety KPV, derived from a naturally occurring human peptide (alpha-MSH), has shown minimal side effects in research settings
This medication was FDA-approved in 2019 for the treatment of hypoactive sexual desire in premenopausal women
Inhibitors of FSP1 and inhibition of ACSL4 (e.g., through a high-fat diet) can increase and decrease the sensitivity of cancer cells to ferroptosis, respectively [241, 242]
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