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Upon transfection or transduction with genes encoding for one or multiple drug metabolizing enzyme genes, HepG2 cells have been shown to be a valuable model system to study the role of bioactivating enzymes in the cytotoxicity of toxicants (Vignati et al., 2005

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In mice from the negative control group (microphotograph 2), a loss of neuronal tissue integrity was observed, marked by the presence of hyperchromatic cells (Figures 12A,B), degradation of the polymorphic, granular, and molecular layers, and necrosis (Figure 12C)